abstract：BACKGROUND:Several publications reported on the safety and efficacy of bortezomib, a novel first-in-class anti-cancer agent, in the treatment of relapsed/refractory multiple myeloma in controlled clinical trials. Complementary data on the experience with bortezomib in daily oncology practice are needed. We report on th...

journal_title：Swiss medical weekly

authors： Freimann H,Calderoni A,Cornu P,Olie R

更新日期：2007-06-02 00:00:00

abstract：:The ex utero intrapartum treatment (EXIT) procedure is designed to guarantee sufficient oxygenation for a foetus at risk of airway obstruction. This is achieved by improving lung ventilation, usually by establishing an airway during caesarean delivery whilst preserving the foetal-placental circulation temporarily. Ind...

journal_title：Swiss medical weekly

authors： Kern C,Ange M,Morales,Peiry B,Pfister RE

更新日期：2007-05-19 00:00:00

abstract：:Increased survival rates after orthotopic liver transplantation (OLT) in patients with end-stage liver disease have become possible due to an advanced understanding of the pathophysiology of liver disease, the establishment of multiorgan procurement and preservation techniques, and the development of safer and more po...

journal_title：Swiss medical weekly

authors： Glanemann M,Busch T,Neuhaus P,Kaisers U

更新日期：2007-04-07 00:00:00

abstract：OBJECTIVES:To assess adherence to recommended standards of diabetes care by Swiss primary care physicians. METHODS:Medical files of community-based primary care physician were reviewed to assess adherence to recommended standards of diabetes care. These standards of care were based on a uniform set of definitions addr...

journal_title：Swiss medical weekly

authors： Bovier PA,Sebo P,Abetel G,George F,Stalder H

更新日期：2007-03-24 00:00:00

abstract：OBJECTIVE:To measure medical care and pharmaceutical drug use among Swiss primary care physicians and its determinants. DESIGN:Cross-sectional mailed survey. SETTING:1784 randomly selected Swiss primary care physicians, including general practitioners, internists and paediatricians. RESULTS:Twenty one percent (95% C...

journal_title：Swiss medical weekly

authors： Schneider M,Bouvier Gallacchi M,Goehring C,Künzi B,Bovier PA

更新日期：2007-02-24 00:00:00

abstract：:According to World Health Organisation estimates 1.1 billion people were overweight or obese worldwide in the year 2000 with the prevalence rapidly increasing. Compelling evidence suggests that excess body weight is a risk factor for several cancer types including cancer of the colon, breast, endometrium, kidney, oeso...

journal_title：Swiss medical weekly

authors： Ceschi M,Gutzwiller F,Moch H,Eichholzer M,Probst-Hensch NM

更新日期：2007-01-27 00:00:00

abstract：BACKGROUND:Adverse reactions to nonsteroidal antiinflammatory drugs (NSAIDs) are frequently reported, particularly among asthmatic patients. To date, there is no causal treatment available apart from tolerance induction. Therefore, the search for safe alternative drugs is of pivotal importance in clinical practice. OB...

journal_title：Swiss medical weekly

authors： Roll A,Wüthrich B,Schmid-Grendelmeier P,Hofbauer G,Ballmer-Weber BK

更新日期：2006-10-28 00:00:00

abstract：OBJECTIVES AND METHODS:Gender differences regarding 17 childhood experiences, thought to have traumatising potential (Traumatic Childhood Experiences = TCE), and pain behaviour in adulthood were assessed using a self-administered, anonymously filled-out questionnaire. Patients were consecutively accrued in the offices ...

journal_title：Swiss medical weekly

authors： Unternährer I,Minder CE,Adler RH

更新日期：2006-09-30 00:00:00

abstract：OBJECTIVES:To investigate the subjective treatment goals of insulin-treated diabetic patients. METHODS:297 type 1 and 205 type 2 diabetic patients, representative of the North-western Swiss population, filled out a self report questionnaire focusing on their own treatment goals using standardized measures wherever ava...

journal_title：Swiss medical weekly

authors： Puder JJ,Endrass J,Moriconi N,Keller U

更新日期：2006-09-02 00:00:00

abstract：QUESTIONS UNDER STUDY:Postmenopausal women are more likely to develop coronary artery disease than premenopausal women of the same age. Postmenopausal oral oestrogen therapy is associated with increased levels of high-density lipoprotein (HDL) cholesterol and decreased levels of lowdensity lipoprotein (LDL) cholesterol...

journal_title：Swiss medical weekly

authors： Delibasi T,Kockar C,Celik A,Kockar O

更新日期：2006-08-05 00:00:00

abstract：:Although progress has been made in the management of acute leukaemias, most patients who fail to respond to front-line therapies with cytostatic agents and stem cell transplantation, or who relapse after an initial response die from progressive disease. Novel treatment modalities exploiting donor-derived natural kille...

journal_title：Swiss medical weekly

authors： Wodnar-Filipowicz A,Kalberer CP

更新日期：2006-06-10 00:00:00

abstract：PRINCIPLES:3435C>T, a single nucleotide polymorphism (SNP) in exon 26 of the MDR1 gene, is linked to the variability of P-gp expression and function among different individuals. It was found that ethnic differences exist in the polymorphism of the MDR1(C3435T) gene. However, the distribution of 3435C>T genotypes in the...

journal_title：Swiss medical weekly

authors： Li Y,Wang Y,Sun J,Li Y,Yang L

更新日期：2006-06-10 00:00:00

abstract：PRINCIPLES:Heart failure is associated with a grim prognosis. Disease management programmes can improve prognosis in heart failure patients but the applicability to the general population remains limited. We aimed to compare the outcome, pharmacological therapy, and quality of life in unselected heart failure patients ...

journal_title：Swiss medical weekly

authors： Lainscak M,Keber I

更新日期：2006-04-29 00:00:00

abstract：BACKGROUND:General practitioners (GPs) use diagnostic tests to help distinguish between viral and bacterial acute respiratory tract infections (ARTI). We investigated the prevalence of these tests, and how tests are associated with diagnosis, treatment and patient satisfaction. METHODS:As part of a clinical trial, 45 ...

journal_title：Swiss medical weekly

authors： Briel M,Young J,Tschudi P,Hersberger KE,Hugenschmidt C,Langewitz W,Bucher HC

更新日期：2006-04-15 00:00:00

abstract：BACKGROUND:In contrast to quality of life, patient satisfaction on chronic haemodialysis (HD) and peritoneal dialysis (PD) has only rarely been studied. PATIENTS AND METHODS:All chronic HD and PD patients of the 19 centres located in western Switzerland were asked to complete a specific questionnaire, assessing dialys...

journal_title：Swiss medical weekly

authors： Wasserfallen JB,Moinat M,Halabi G,Saudan P,Perneger T,Feldman HI,Martin PY,Wauters JP

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Sleep disturbances are prevalent but often overlooked or underestimated. We suspected that sleep disorders might be particularly common among pharmacy customers, and that they could benefit from counselling. Therefore, we described the prevalence and severity of symptoms associated with sleep a...

journal_title：Swiss medical weekly

authors： Schwegler K,Klaghofer R,Nirkko AC,Mathis J,Hersberger KE,Bloch KE

更新日期：2006-03-04 00:00:00

abstract：QUESTIONS UNDER STUDY/PRINCIPLES:We describe the proportion of severely depressed outpatients reaching complete remission at the different stages of a drug treatment algorithm. We compare several treatment options for SSRI (selective serotonin reuptake inhibitor) non-responders and test the feasibility of the algorithm...

journal_title：Swiss medical weekly

authors： Bondolfi G,Aubry JM,Golaz J,Gex-Fabry M,Gervasoni N,Bertschy G

更新日期：2006-02-04 00:00:00

abstract：:Apart from the degree of stenosis, plaque morphology has emerged in recent years as an important contributory factor in stroke risk. Ultrasound studies have shown that hypo- or anechogenic plaques carry a higher risk of cerebrovascular events than echogenic ones. Similarly, heterogeneous plaques presenting a complex p...

journal_title：Swiss medical weekly

authors： Sztajzel R

更新日期：2005-10-29 00:00:00

abstract：INTRODUCTION:Graft rejection and infection remain major morbidities following orthotopic liver transplantation (OLT). Rejection treatment may be associated with an increased rate of infectious complications. The aim of this study was to determine the relationship between rejection, rejection therapy and the risk of ass...

journal_title：Swiss medical weekly

authors： Garbino J,Romand JA,Pittet D,Giostra E,Mentha G,Suter P

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:To study the association between maternal smoking during pregnancy and low birth weight (LBW), small-for-gestational-age birth weight (SGA) and preterm birth, and to quantify the population-attributable fractions for these outcomes in Switzerland. METHODS:Data were gathered for all births in the Canton of Vaud...

journal_title：Swiss medical weekly

authors： Chiolero A,Bovet P,Paccaud F

更新日期：2005-09-03 00:00:00

abstract：BACKGROUND AND AIM:Perinatal and infant mortality rates are considered key indicators of medical care. The aim of this investigation was to examine how representative and reliable the official national figures of Switzerland are by comparing them with the data in local birth registers. METHODS:124 of 156 maternity hos...

journal_title：Swiss medical weekly

authors： Müller M,Drack G,Schindler C,Bucher HU

更新日期：2005-07-23 00:00:00

abstract：BACKGROUND:Carbon monoxide (CO) poisoning is associated with a wide range of non-specific symptoms, whose time course and prognostic significance are ill defined. METHODS:We observed a large CO poisoning in a homogenous cohort of 38 male recruits and compared their symptoms with those of 46 unexposed controls from the...

journal_title：Swiss medical weekly

authors： Henz S,Maeder M

更新日期：2005-07-09 00:00:00

abstract：:The differential diagnosis for children with diabetes includes a group of monogenic diabetic disorders known as maturity-onset diabetes of the young (MODY). So far, six underlying gene defects have been identified. The most common subtypes are caused by mutations in the genes encoding the transcription factor HNF-1a (...

journal_title：Swiss medical weekly

authors： Schnyder S,Mullis PE,Ellard S,Hattersley AT,Flück CE

更新日期：2005-06-11 00:00:00

abstract：:Atrial arrhythmias complicate the clinical course of adult patients with an atrial septal defect. Atrial flutter is more prevalent in younger patients, and frequently regresses after surgical defect closure. Atrial fibrillation however, which results from a chronic underlying disease, rarely reverts to sinus rhythm af...

journal_title：Swiss medical weekly

authors： Berger F,Vogel M,Kretschmar O,Dave H,Prêtre R,Dodge-Khatami A

更新日期：2005-03-19 00:00:00

abstract：:Pulmonary rehabilitation is a form of therapy for patients with chronic lung disease that is evidence based, which ameliorates performance and endurance of the patient and improves quality of life significantly. Pulmonary rehabilitation also diminishes the amount of hospitalisations and the duration of stay in hospita...

journal_title：Swiss medical weekly

authors： Karrer W

更新日期：2005-02-05 00:00:00

abstract：:The atherogenic lipoprotein phenotype is characterised by a moderate increase in plasma triglycerides, a decrease in high density lipoprotein cholesterol and the prevalence of smaller denser low density lipoprotein particles. The prevalence of this partially inheritable phenotype is approximately 30% and is a feature ...

journal_title：Swiss medical weekly

authors： Berneis K,Rizzo M

更新日期：2004-12-18 00:00:00

abstract：BACKGROUND:Epidemiological studies focusing on first-ever seizures have been carried out mainly on community based populations. However, since hospital populations may display varying clinical features, we prospectively analysed patients with first-ever seizure in a hospital based community to evaluate prognosis and th...

journal_title：Swiss medical weekly

authors： Kawkabani A,Rossetti AO,Despland PA

更新日期：2004-10-02 00:00:00

abstract：BACKGROUND:To compare the efficacy of two different regimens in treatment of brucellosis. METHODS:This randomised clinical trial study was conducted on 280 patients with brucellosis in Babol, Iran, from April 1999 to January 2002. One of the following two regimens was randomly prescribed for two months: co-trimoxazole...

journal_title：Swiss medical weekly

authors： Roushan MR,Gangi SM,Ahmadi SA

更新日期：2004-09-18 00:00:00

abstract：:Antibiotics account for a substantial proportion of hospital drug expenditures and tend to be misused or overused, generating unnecessary costs and causing the emergence of resistant bacteria. Antibiotic use was evaluated in a one-day prevalence study performed on the surgical and medical wards of eight Swiss non-univ...

journal_title：Swiss medical weekly

authors： Bugnon-Reber A,de Torrenté A,Troillet N,Genné D,ETUDAS group.

更新日期：2004-08-21 00:00:00

abstract：OBJECTIVE:Cerebral hydatid disease is very rare, representing only 2% of all cerebral space occupying lesions even in the countries where the disease is endemic. The aim of this paper is to describe the characteristic features of cerebral hydatid disease in computed tomography (CT) and magnetic resonance imaging (MRI)....

journal_title：Swiss medical weekly

authors： Bükte Y,Kemaloglu S,Nazaroglu H,Ozkan U,Ceviz A,Simsek M

更新日期：2004-08-07 00:00:00

abstract：:This paper focuses on the relationships between schizophrenia and religion, on the basis of a review of literature and the data of an ongoing study about religiousness and spiritual coping conducted among outpatients with chronic schizophrenia. Religion (including both spirituality and religiousness) is salient in the...

journal_title：Swiss medical weekly

authors： Mohr S,Huguelet P

更新日期：2004-06-26 00:00:00

abstract：:Isolated left ventricular hypertrophy, in the absence of hypertension or aortic stenosis, is commonly attributed to hypertrophic cardiomyopathy (HCM). According to the clinical setting, however, other differential diagnoses should be considered. The diagnosis of cardiac amyloidosis may be very challenging especially w...

journal_title：Swiss medical weekly

authors： Bonvini RF,Camenzind E

更新日期：2004-05-15 00:00:00

abstract：:We report on two toddlers suffering from Mycobacterium bohemicum lymphadenitis. Acid-fast bacilli were cultured from submandibular lymph nodes and identified by molecular methods as Mycobacterium bohemicum. Surgical treatment was successful and complemented by oral treatment with clarithromycin and rifampicin. ...

journal_title：Swiss medical weekly

authors： Schulzke S,Adler H,Bär G,Heininger U,Hammer J

更新日期：2004-04-17 00:00:00

abstract：:A 36-year-old male with a known history of sickle cell disease (SCD) and acute chest syndrome (ACS) was treated in our hospital. Gas exchange deteriorated and the patient was transferred to our intensive care unit (ICU). Low dose inhaled nitric oxide (iNO) during pressure controlled mechanical ventilation (pcMV) induc...

journal_title：Swiss medical weekly

authors： Oppert M,Jörres A,Barckow D,Eckardt KU,Frei U,Kaisers U

更新日期：2004-03-20 00:00:00

abstract：BACKGROUND:B-type natriuretic peptide (BNP) has been proven to be a biochemical marker of severity of congestive heart failure. We are aware of only few papers reporting the association of BNP elevation and pulmonary hypertension (primary, thromboembolic, or as a consequence of chronic obstructive pulmonary disease). L...

journal_title：Swiss medical weekly

authors： Maeder M,Ammann P,Rickli H,Diethelm M

更新日期：2003-09-26 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic and usually progressive lung disorder of unknown aetiology. Conventional management of patients with IPF has been primarily based on the concept that suppressing inflammation would prevent progression to fibrosis. Although the pathogenesis is incompletely understood, it...

journal_title：Swiss medical weekly

authors： Geiser T

更新日期：2003-07-26 00:00:00

abstract：OBJECTIVES:Women are still underrepresented in the senior ranks of medical school faculties. Thus far information has been lacking on gendersensitive career paths for professorial and nonprofessorial staff of Swiss medical schools. The aim of this study was to survey faculty members of all Swiss medical schools on soci...

journal_title：Swiss medical weekly

authors： Buddeberg-Fischer B,Leemann R,Klaghofer R

更新日期：2003-05-31 00:00:00

abstract：:Amyloid fibrils are polymers composed of proteins in beta-sheet conformation, which are found in at least 20 diseases for which no cure is available. These diseases include Alzheimer's disease and spongiform encephalopathies, in which the amyloid beta-peptide and the prion protein (PrP), respectively, form amyloid. Al...

journal_title：Swiss medical weekly

authors： Johansson J

更新日期：2003-05-17 00:00:00

abstract：:Dementia with Lewy bodies (DLB) accounts for 15-20% of all autopsy confirmed dementias in old age. Characteristic histopathological changes are intracellular Lewy bodies and Lewy neurites, with abundant senile plaques but sparse neurofibrillary tangles. Core clinical features are fluctuating cognitive impairment, pers...

journal_title：Swiss medical weekly

authors： Mosimann UP,McKeith IG

更新日期：2003-03-08 00:00:00

abstract：:Over the last few years atypical antipsychotics have been used increasingly in the pharmacological treatment of schizophrenia. This review provides an overview of the pharmacological and clinical characteristics of atypical antipsychotics. In particular we discuss their efficacy in treating psychotic and negative symp...

journal_title：Swiss medical weekly

authors： Bridler R,Umbricht D

更新日期：2003-02-08 00:00:00